Compositions and methods for inhibiting inflammation

US11202850B2 · kind B2 · utility

Assignees

• The University of Memphis Research Foundation · US
• University of Tennessee Research Foundation · US

Inventors

• Gary Bowlin · Mechanicsville, US
• Allison E. Fetz · Memphis, US
• Marko Z. Radic · Memphis, US

Key dates

• Filing date: Mar 11, 2019
• Grant date: Dec 21, 2021
• Expiry date: Mar 11, 2039

Classification

• Technology area (CPC D): Textiles; Paper
• CPC primary: D01F6/625
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).