Prodrug and profluorescent compounds for selective mitochondrial imaging and therapeutic targeting
US11203583B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Feb 6, 2020 |
| Grant date | Dec 21, 2021 |
| Priority date | — |
| Expiry date | Feb 6, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/582
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.