Thioester prodrugs of macrocycles as inhibitors of histone deacetylases
US11203602B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | May 18, 2017 |
| Grant date | Dec 21, 2021 |
| Priority date | — |
| Expiry date | Jul 8, 2037 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.