Eukaryotic cells and methods for recombinantly expressing a product of interest

US11203631B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Thomas Jostock · Neuenburg am Rhein, DE
• Holger Laux · Irslingen, DE
• Anett RITTER · Weil am Rhein, DE

Key dates

• Filing date: Dec 18, 2014
• Grant date: Dec 21, 2021
• Expiry date: Oct 27, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2511/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The disclosure pertains to novel eukaryotic cell suitable for recombinant production of a product of interest, wherein the effect of the expression product of an endogenous gene C12orf35 is impaired in said cell, thereby increasing their productivity when recombinantly expressing a polypeptide of interest. Furthermore, the present disclosure provides associated technologies wherein such host cells are used in recombinant production technologies.