Dual-function starch-based composite nanoparticles as well as preparation method and application thereof
US11203647B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 13, 2020 |
| Grant date | Dec 21, 2021 |
| Priority date | — |
| Expiry date | Apr 29, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/412
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application discloses dual-function starch-based composite nanoparticles as well as a preparation method and application thereof. The preparation method comprises: hydrolyzing starch to form linear dextrin, grading the linear dextrin by using an alcohol-alcohol gradient precipitation method to obtain linear dextrin having homogeneous molecular weight distribution; oxidizing the linear dextrin by adopting an oxidation system to obtain oxidized dextrin; carrying out complex reaction on the oxidized dextrin and curcumin to form an oxidized dextrin-curcumin complex; and forming an oxidized dextrin-curcumin/chitosan hydrochloride composite nanoparticles from the oxidized dextrin-curcumin complex and chitosan hydrochloride. The aqueous phase solution of the dual-function starch-based composite nanoparticles containing gel polysaccharide is uniformly mixed with primary emulsion, calcium ion induction is carried out on the obtained double emulsion to obtain double-emulsion gel.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.