Microbial oil containing fatty acids obtained from stramenopile and method of producing the same

US11203763B2 · kind B2 · utility

Assignee

• KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION · JP

Inventors

• Keishi Sakaguchi · Fukuoka, JP
• Rie Hamaguchi · Fukuoka, JP
• Takanori Matsuda · Itoshima, JP
• Makoto Ito · Okazaki, JP
• Naoki Nagano · Miyazaki, JP
• Masahiro Hayashi · Sakata, JP
• Yuji Okita · Chofu, JP
• Shinichi Sugimoto · Tokyo, JP
• Daisuke Honda · Sakai, JP

Key dates

• Filing date: Dec 3, 2018
• Grant date: Dec 21, 2021
• Expiry date: Feb 18, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/14
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A microbial oil is obtained from Labyrinthulomycetes in which a gene for fatty acid biosynthesis has been disrupted or an expression of the gene has been inhibited to highly accumulate the fatty acid. The microbial oil typically contains: (a) 1.5% or more of arachidonic acid (AA) based on a total amount of fatty acid; (b) 0.2% or more of dihomo-γ-linolenic acid (DGLA) based on the total amount of fatty acid; (c) 0.04% or more of eicosatetraenoic acid (ETA) based on the total amount of fatty acid; (d) 3.8% or more of eicosapentaenoic acid (EPA) based on the total amount of fatty acid; (e) 13.7% or less of n-6 docosapentaenoic acid (n-6DPA) based on the total amount of fatty acid; and (f) 43.9% or less of docosahexaenoic acid (DHA) based on the total amount of fatty acid.