Enriched multilayer amnion derived tissue graft
US11207355B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 1, 2018 |
| Grant date | Dec 28, 2021 |
| Priority date | — |
| Expiry date | Sep 1, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2240/001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An enriched amnion derived tissue graft has a stromal matrix layer and an epithelium layer. A stromal matrix layer may contain a basement membrane layer, a compact layer, a fibroblast layer, and an intermediate layer. An amnion derived tissue graft may have a plurality of tissue layers and the layers may be configured with the epithelium layers toward the inside and the stromal matrix layers toward the outside surface. An enriched portion may be coated onto or be configured within a tissue layer and have an increased concentration of cells, of proteins, growth factors, seed cells, pharmaceuticals or any combination thereof. A carrier fluid such as amniotic fluid may be used to produce an enrichment composition for coating the tissue graft. The cells within the enriched portion may be stem cells from the amnion, or cells from other tissue and may be seed cells selected based on the treatment location.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.