Anti-resorptive and bone building dietary supplements and methods of use

US11207368B2 · kind B2 · utility

Inventors

• David W. Krempin · Temecula, US
• Mary A. Murray · Irvine, US
• Yumei Lin · Long Beach, US
• Kevin W. Gellenbeck · Poway, US
• Silvia R. da Costa · Los Angeles, US
• Leon M. Wilkins · North Andover, US
• Haeri Roh-Schmidt · Stockton, US
• Jatinder Rana · Grand Rapids, US
• John F. Rebhun · Greenville, US
• David J. Fast · Grand Rapids, US

Key dates

• Filing date: Aug 12, 2016
• Grant date: Dec 28, 2021
• Expiry date: Oct 26, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A23V2002/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.