Viscosity reduction of highly concentrated protein formulations

US11207412B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Martin Zillmann · Billerica, US
• Alexandra KROG · Bodenheim, DE
• Raphael Guebeli · Darmstadt, DE
• Tanja Henzler · Schriesheim, DE
• Christian HILDEBRANDT · Heppenheim, DE

Key dates

• Filing date: Apr 16, 2019
• Grant date: Dec 28, 2021
• Expiry date: Jun 26, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity. The contained proteins in the prepared formulations are stabilized against aggregation and denaturation and are thus sufficiently storage-stable until administration to the patient.