Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags

US11207421B2 · kind B2 · utility

Assignees

• The Research Foundation for The State University of New York · US
• PATH · US

Inventors

• Jonathan Lovell · Toronto, CA
• Shuai Shao · Hangzhou City, CN
• Jumin Geng · Williamsville, US
• Wei Huang · 红钢城街道, CN
• Shwu-Maan Lee · Rockville, US
• Charles Richter King · Washington, US

Key dates

• Filing date: Apr 30, 2019
• Grant date: Dec 28, 2021
• Expiry date: Jul 22, 2039

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules comprising epitopes from microorganisms with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated to the cobalt metal core and the presentation molecules are exposed to the outside of the nanostructures. The nanostructures can further comprise a cargo. The nanostructures can be used to deliver the cargo to an individual.