N-substituted imidazole carboxylate compound, preparation method and use

US11208385B2 · kind B2 · utility

Assignee

• WEST CHINA HOSPITAL, SICHUAN UNIVERSITY · CN

Inventors

• Jin Liu · Beijing, CN
• Jun Yang · Oak Ridge, US
• Wensheng Zhang · Sichuan, CN
• Bowen KE · Sichuan, CN
• Lei Tang · Zhenjiang, CN
• Bin Wang · Beijing, CN

Key dates

• Filing date: Jan 31, 2018
• Grant date: Dec 28, 2021
• Expiry date: Jul 22, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/90
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An N-substituted imidazole carboxylate compound is of formula (I). In formula (I), C* is an R-type chiral carbon atom, R1 and R2 are independently selected from H, methyl, ethyl, cyclopropyl, cyclobutyl or isopropyl, or R1 and R2 form a C2˜5 alkylenyl group; R3 is a substituted or unsubstituted C1-18 saturated or unsaturated aliphatic hydrocarbon or aromatic hydrocarbon, in which the aliphatic hydrocarbon comprises a straight chain, branched chain or cyclic aliphatic hydrocarbyl. The compound or pharmaceutically acceptable salts thereof can be used to prepare central inhibitory drugs that exert sedative, hypnotic and/or anesthetic effects on humans or animals, and can produce rapid and reversible anesthetic effects, and can be rapidly metabolized into an inactive etomidate acid, and after drug withdrawal, the wake-up quality is good; and the body's corticosteroid function can be rapidly recovered after a single administration or continuous administration.