Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof

US11208400B2 · kind B2 · utility

Assignees

• BAYER HEALTHCARE LLC · DE
• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Anja GIESE · Berlin, DE
• Jürgen Klar · Wuppertal, DE
• Alexander Helmut Michael EHRMANN · Cambridge, US
• Jens WILLWACHER · Biberach an der Riß, DE
• David Birenbaum Engel · Bloomington, US
• Andre DIESKAU · Wuppertal, DE
• Antje Kahnert · Wuppertal, DE
• Alexey GROMOV · Erkrath, DE
• Carsten Schmeck · Wuppertal, DE
• Niels Lindner · Wuppertal, DE
• Thomas Müller · Bonn, DE
• Anna Lena ANDREEVSKI · Solingen, DE
• Jan DREHER · Wuppertal, DE
• Karl COLLINS · Düsseldorf, DE

Key dates

• Filing date: Oct 9, 2017
• Grant date: Dec 28, 2021
• Expiry date: Oct 9, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.