Immunoglobulin-binding polypeptide
US11208441B2 · kind B2 · utility
0Cited by
2References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 19, 2016 |
| Grant date | Dec 28, 2021 |
| Priority date | — |
| Expiry date | Mar 17, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/705
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An object of the present invention is to provide a polypeptide having a high binding capacity for an immunoglobulin kappa chain, and having excellent alkali stability, by modifying an amino acid sequence of an immunoglobulin-binding domain of Protein L derived from Peptostreptococcus magnus. A polypeptide having a high binding capacity for an immunoglobulin kappa chain, and having excellent alkali stability can be obtained by substituting specific lysine residues in an immunoglobulin-binding domain of Protein L derived from Peptostreptococcus magnus 3316 strain, with a basic amino acid or a hydroxyl group-containing amino acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.