Compositions and methods for treating cancer with DuoCARs

US11208455B2 · kind B2 · utility

Assignee

• LENTIGEN TECHNOLOGY, INC. · US

Inventors

• Rimas J. Orentas · Seattle, US
• Dina Schneider · Potomac, US
• Waleed M. Haso · Santa Monica, US
• Stefan Miltenyi · Wittlich, DE
• Boro Dropulic · Ellicott City, US

Key dates

• Filing date: Nov 22, 2019
• Grant date: Dec 28, 2021
• Expiry date: Nov 22, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2840/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel therapeutic immunotherapy compositions comprising at least two vectors, each vector encoding a functional CAR, whereby the combination of vectors results in the expression of two or more non-identical binding domains, wherein each vector encoded binding domain(s) are covalently linked to a transmembrane domain and one or more non-identical intracellular signaling motifs are provided herein as well as are methods of use of same in a patient-specific immunotherapy that can be used to treat cancers and other diseases and conditions.