Methods of increasing progranulin levels using anti-Sortilin antibodies

US11208488B2 · kind B2 · utility

Assignee

• Alector LLC

Inventors

• Arnon Rosenthal · Woodside, US
• Tina SCHWABE · San Francisco, US
• Michael Kurnellas · San Francisco, US
• Robert Pejchal · Hartford, US
• Anthony B. Cooper · South San Francisco, US

Key dates

• Filing date: Sep 18, 2018
• Grant date: Dec 28, 2021
• Expiry date: Sep 18, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.