Mitochondrial genome editing and regulation
US11208652B2 · kind B2 · utility
2Cited by
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7Claims
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Key dates
| Filing date | Feb 2, 2017 |
| Grant date | Dec 28, 2021 |
| Priority date | — |
| Expiry date | Jun 18, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions of altering mitochondrial DNA of a eukaryotic cell are provided using one or more of a mitochondrial specific adeno-associated virus to deliver one or more nucleic acids encoding CRISPR system including a Cas9 protein or its nuclease inactive variant and a guide RNA into a mitochondria for expression within the mitochondria. The Cas9 system can cut, nick or regulate a target mitochondrial nucleic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.