T cell balance gene expression, compositions of matters and methods of use thereof

US11209440B2 · kind B2 · utility

Inventors

• Vijay K. Kuchroo · Newton, US
• Aviv Regev · Cambridge, US
• Jellert Gaublomme · Cambridge, US
• Youjin Lee · Suwon-si, KR
• Alexander K. Shalek · Cambridge, US
• Chao Wang · State College, US
• Nir Yosef · Richmond, US
• Hongkun Park · Lexington, US

Key dates

• Filing date: Aug 24, 2016
• Grant date: Dec 28, 2021
• Expiry date: Apr 20, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.