Image analysis for breast cancer prognosis

US11211167B2 · kind B2 · utility

Assignees

• Ventana Medical Systems, Inc. · US
• The Cleveland Clinic Foundation · US
• The University of Melbourne · AU

Inventors

• Srinivas Chukka · San Jose, US
• Olcay Sertel · Sunnyvale, US
• Anindya Sarkar · Milpitas, US
• Nikolaus Wick · Innsbruck, AT
• Shalini Singh · Tucson, US
• Crystal Schemp · Tucson, US
• Paul Waring · Melbourne, AU
• Raymond Tubbs · Cleveland, US

Key dates

• Filing date: Dec 19, 2013
• Grant date: Dec 28, 2021
• Expiry date: Jun 9, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/54
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Heterogeneity for biomarkers in a tissue sample can be calculated. A heterogeneity score can be combined with an immunohistochemistry combination score to provide breast cancer recurrence prognosis. Heterogeneity can be based on percent positivity determinations for a plurality of biomarkers according to how many cells in the sample stain positive. An immunohistochemistry combination score can be calculated. An imaging tool can support a digital pathologist workflow that includes designating fields of view in an image of the tissue sample. Based on the fields of view, a heterogeneity metric can be calculated and combined with an immunohistochemistry combination score to generate a breast cancer recurrence prognosis score.