Cartilage regeneration composition containing HAPLN1 as active ingredient
US11213572B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 28, 2020 |
| Grant date | Jan 4, 2022 |
| Priority date | — |
| Expiry date | Feb 28, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P19/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a method of regenerating cartilage tissues by treatment with hyaluronan and proteoglycan link protein 1 (HAPLN1), and a composition for regenerating cartilage, the composition including HAPLN1 as an active ingredient. According to the present disclosure, the HAPLN1 protein may have cartilage formation-stimulating ability and articular cartilage regeneration ability, may increase an expression level of TGF-β receptor I of chondrocytes to increase a component ratio of cells having cartilage formation ability, and to induce regeneration of cartilage tissues. Accordingly, the HAPLN1 protein of the present disclosure, which is a novel composition regulating TGF-β signaling, may be usefully applied as a pharmaceutical composition for regenerating cartilage, a health food composition for regenerating cartilage, or a reagent composition for regenerating cartilage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.