Methods for safe and effective thrombolysis using sequential administration of tissue plasminogen activator and mutant pro-urokinase
US11213574B2 · kind B2 · utility
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Key dates
| Filing date | Nov 3, 2015 |
| Grant date | Jan 4, 2022 |
| Priority date | — |
| Expiry date | Nov 3, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21073
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are methods for safe and effective thrombolysis in therapy for human subjects with symptoms of a potential stroke or acute myocardial infarction (“AMI”) using a sequential administration of a low dose bolus of human tissue plasminogen activator (“tPA”) followed by an infusion of a mutant form of human pro-urokinase (“proUK”).
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