SSTR-targeted conjugates and particles and formulations thereof
US11213590B2 · kind B2 · utility
0Cited by
2References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 27, 2017 |
| Grant date | Jan 4, 2022 |
| Priority date | — |
| Expiry date | Oct 27, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/72
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.