Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids
US11213594B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Apr 28, 2017 |
| Grant date | Jan 4, 2022 |
| Priority date | — |
| Expiry date | Apr 28, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/86
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are compositions for delivering gene editing molecules to a cell. Exemplary compositions comprise a micelle assembled from a plurality of triblock copolymers, wherein each triblock copolymer having at least one hydrophobic block, at least one hydrophilic block, and at least one poly(L-histidine) block, wherein: the at least one poly(L-histidine) block complexes with the at least one gene editing molecule; and the at least one poly(L-histidine) block is capable of a pH dependent release of the at least one gene editing molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.