Cross-linked bioprosthetic tissue using bio-orthogonal binding pairs
US11213611B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 21, 2019 |
| Grant date | Jan 4, 2022 |
| Priority date | — |
| Expiry date | Mar 25, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/40
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Methods for treating a bioprosthetic tissue and treated bioprosthetic tissue are described. The methods comprise contacting the biological tissue with an anchor compound, the anchor compound comprising first and second functional groups. The first functional group is reactive with and couples a tissue functional group associated with the biological tissue. The second functional group is one of a bio-orthogonal binding pair. The biological tissue coupled to the anchor compound is then exposed to a linking compound. The linking compound comprises at least two functional groups, each comprising the other one of the bio-orthogonal binding pair. In a preferred embodiment, the bio-orthogonal binding pair is an azide and an acetylene. The method can be performed in the presence of a catalyst, preferably a copper catalyst. Alternatively, the method can be performed in the absence of a catalyst, wherein the acetylene is incorporated in a ring-strained cyclic compound, such as cyclooctyne.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.