Method for preparing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
US11214553B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Sep 18, 2017 |
| Grant date | Jan 4, 2022 |
| Priority date | — |
| Expiry date | Dec 24, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D257/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a method for preparing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) of formula (II), comprising the following steps: carrying out an alkylation reaction on cyclen in formula (I) and XCH2COOR in the presence of an acid-binding agent in water; adjusting a pH value to separate out a crude product of DOTA; and recrystallizing. The preparation method of the present invention is applicable to large-scale industrial production of DOTA, the whole process does not need to adopt an ion-exchange resin or low-temperature refrigeration mode for purification, and the purity and yield of the product are higher.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.