Patent · US Active

Engineered FHA domains

US11214791B2 · kind B2 · utility

0Cited by

0References

14Claims

0Family size

Assignee

Idea Orchard, LLC · US

Inventors

Rajika Perera · Pasadena, US
Michael Longo · Whittier, US

Key dates

Filing date	Apr 25, 2017
Grant date	Jan 4, 2022
Priority date	—
Expiry date	Apr 25, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC40B40/10
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A binding agent to a target molecule, or method or kit where the binding agent is selected from a library where each variant has a circular permutation of the FHA domain where the rearrange does not substantially disrupt the FHA domain's beta-sheet scaffold or increase the stability of the beta-sheet scaffold. The randomized regions of the FHA domain include the endogenous binding interface the FHA domain, the region opposite of the endogenous binding interface, and the circular permutation region.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.