Methods of cancer treatment using activated T cells

US11219675B2 · kind B2 · utility

Assignee

• SYZ Cell Therapy Co. · CN

Inventors

• Xiangjun Zhou · Tangxia, CN
• Jin LI · Tangxia, CN
• Yanyan Han · Lafayette, US
• Dongyun WU · Tangxia, CN
• Junyun LIU · Nanhu, CN
• Ran Tao · Amsterdam, NL
• Longqing TANG · Longbeilingcun, CN

Key dates

• Filing date: Dec 8, 2020
• Grant date: Jan 11, 2022
• Expiry date: Dec 8, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2502/1121
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.