Methods and compositions for treating and preventing HIV

US11219683B2 · kind B2 · utility

Assignees

• INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE M{circumflex over (D)}DICALE (INSERM) · FR
• Université Paris—Est Créteil Val de Marne · FR
• ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS (APHP) · FR
• BAYLOR RESEARCH INSTITUTE · US

Inventors

• Yves Levy · Malakoff, FR
• Gerard Zurawski · San Juan Bautista, US
• Sandra Zurawski · Midlothian, US
• Anne-Laure Flamar · New York, US

Key dates

• Filing date: Jun 19, 2020
• Grant date: Jan 11, 2022
• Expiry date: Jul 2, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16171
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions are provided that can be used to vaccinate against and treat HIV. Specifically contemplated are vaccine compositions and methods of using these compositions treat HIV in patients. Aspects of the disclosure relate to an anti-CD40 antibody-HIV antigen fusion protein comprising (i) an anti-CD40 heavy chain (HCD40)-HIV antigen (Ag) fusion protein comprising the formula: HCD40-Ag, wherein Ag is a polypeptide with at least 80% sequence identity to SEQ ID NO:1; and (ii) an anti-CD40 light chain (LCD40).