Molecular separation by diffusion using an EWOD device
US11219898B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 15, 2019 |
| Grant date | Jan 11, 2022 |
| Priority date | — |
| Expiry date | Aug 29, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/447
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of operating an electrowetting on dielectric (EWOD) device performs microfluidic diffusion separation. The method includes the steps of: inputting a sample droplet into the EWOD device, wherein the sample droplet includes a mixture of particles including first particles and second particles that are different from each other; inputting a collection droplet into the EWOD device; performing an electrowetting operation to bring the sample droplet into contact with the collection droplet; at an initial time, initiating a process of particle separation by which a portion of the sample droplet is introduced into the collection droplet, wherein the first particles move through the collection droplet at a rate different from the second particles; and after a time interval from the initial time, performing an electrowetting operation to segment a leaving droplet from the collection droplet, wherein the leaving droplet has a higher concentration of the first particles relative to the second particles as compared to a concentration of the first particles relative to the second particles in the sample droplet at the initial time. The method may be performed by an AM-EWOD control syste…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.