Glucosylceramide synthase inhibitors and therapeutic methods using the same

US11220479B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Scott D. Larsen · Kalamazoo, US
• James A. Shayman · Ann Arbor, US
• Kim Hutchings · Dexter, US
• Neil Moss · Ridgefield, US
• Qin Jiang · Latham, US
• Nicholas Mayhew · Niskayuna, US
• Emily Freeman · Voorheesville, US
• Zohreh Sajjadi Hashemi · Frederick, US

Key dates

• Filing date: Oct 22, 2020
• Grant date: Jan 11, 2022
• Expiry date: Oct 22, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.