Process for preparing indole carboxamide compounds

US11220489B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Junying Fan · 安丰镇, CN
• Peng Geng · Fryeburg, US
• Neil A. Strotman · Flemington, US
• Alina Borovika · Brooklyn, US
• Jason Michael Stevens · Cranford, US
• Dimitri Skliar · Staten Island, US

Key dates

• Filing date: Aug 31, 2017
• Grant date: Jan 11, 2022
• Expiry date: Jan 5, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a process for preparing (S)-4-(3-(but-2-ynamido)piperidin fluoro-2,3-dimethyl-1H-indole-7-carboxamide, comprising the steps of: preparing a compound of Formula (III); converting the compound of Formula (III) to a compound of Formula (V); and reacting the compound of Formula (V) with a compound of Formula (VI) to provide (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide.