Defined three dimensional microenvironment for cell culture
US11220669B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 13, 2018 |
| Grant date | Jan 11, 2022 |
| Priority date | — |
| Expiry date | Aug 15, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2535/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described is a three-dimensional (3D) microenvironment presenting defined biochemical and physical cues that regulate cellular behavior and use of the microenvironment. A composition to form the 3D microenvironment is provided by combining one or more natural or synthetic polymeric materials and substrate proteins recombinantly or chemically functionalized with a variety of bioactive peptides such as extracellular matrix-derived or growth factor-derived peptides. Also described are devices and methods for screening for optimal combinations of the bioactive motifs in order to create an extracellular microenvironment that can regulate specific cellular behavior such as cell growth, proliferation, migration or differentiation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.