Predicting immunogenicity of T cell epitopes

US11222711B2 · kind B2 · utility

Assignees

• BIONTECH SE · DE
• TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE

Inventors

• Ugur Sahin · Mainz, DE
• Arbel David Tadmor · Bodenheim, DE
• John Castle · Seattle, US
• Sebastian Boegel · Obermoschel, DE
• Martin Löwer · Bodenheim, DE

Key dates

• Filing date: May 7, 2014
• Grant date: Jan 11, 2022
• Expiry date: Nov 5, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to methods for predicting T cell epitopes. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic or not. The methods of the invention are useful, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.