Patent · US Active

Self-regulating device for modulating inflammation

US11224685B2 · kind B2 · utility

0Cited by

37References

5Claims

0Family size

Assignee

University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

Yoram Vodovotz · Dorpsstraat, US
Alexey Solovyev · Pittsburgh, US
David O. Okonkwo · Pittsburgh, US
Maxim Mikheev · Jefferson Hills, US
Qi Mi · Pittsburgh, US
Jorg Gerlach · Berlin, DE
Gregory M. Constantine · Baden, US

Key dates

Filing date	Oct 10, 2018
Grant date	Jan 18, 2022
Priority date	—
Expiry date	May 21, 2039

Classification

Technology area (CPC B)Performing Operations; Transporting
CPC primaryB01D63/026
WIPO fieldChemical engineering
WIPO sectorChemistry

Abstract

A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.