Malic enzyme inhibitors

US11225480B2 · kind B2 · utility

Assignee

• SUN PHARMA ADVANCED RESEARCH COMPANY LTD. · IN

Inventors

• Gaurav Sanjivkumar Sheth · Vadodara, IN
• Sabbirhusen Yusufbhai Chimanwala · Salumbar, IN
• Tushar Mukund Jarag · Vadodara, IN
• Aishwarya Hampiholi · Pune, IN
• Saikat Maity · Medinipur, IN
• Prabal Sengupta · Salumbar, IN
• Gulamnizami Abdulsattar Qureshi · Vadodara, IN
• Umesh Chaudhari · Bound Brook, US
• Raj Gopal Venkat · Salt Lake City, US
• V. S. N. Murty Kadiyala · Vadodara, IN
• Sairam VVM Kalapatapu · Hyderabad, IN
• Vaibhav Jain · Sagar, IN
• Trinadha Rao Chitturi · Salumbar, IN

Key dates

• Filing date: Oct 16, 2020
• Grant date: Jan 18, 2022
• Expiry date: Oct 16, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans. The novel compounds have a structure according to Formula I or a pharmaceutically acceptable salt, stereoisomer or deuterated analog thereof, wherein X, R1, R2 and Y are as described herein.