Patent · US Active

Synthesis of 1:1:1 co-crystal of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene, L-proline and water

US11225500B2 · kind B2 · utility

1Cited by

0References

11Claims

0Family size

Inventors

Matthias Eckhardt · Hannover, DE
Monika Brink · Ingelheim am Rhein, DE
Frank Himmelsbach · Mittelbiberach, DE
Stefan Sahli · Zofingen, CH
Chutian Shu · Jinan, CN
Xiao-Jun Wang · Danbury, US
Beat Weber · Zofingen, CH
Bing-Shiou Yang · Southbury, US

Key dates

Filing date	Dec 17, 2018
Grant date	Jan 18, 2022
Priority date	—
Expiry date	Dec 17, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/16
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a process for the manufacture of the crystalline compound according to formula (I) comprising the steps (a) deacetylating the final intermediate (FI), (b) forming the crystalline compound according to formula (I) by reacting the deacetylated final intermediate of step (a) with L-proline and water and isolating the final reaction product; processes of manufacturing intermediates thereof; process intermediates and their uses in the processes according to the present invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.