Conformation switchable antimicrobial peptides and methods of using the same

US11225507B2 · kind B2 · utility

Assignee

• The Board of Trustees of the University of Illinois · US

Inventors

• Jianjun Cheng · Champaign, US
• Lin Chen · Champaign, US
• Menghua Xiong · 流花街道, CN
• Yan BAO · 东风镇, CN

Key dates

• Filing date: Jan 25, 2018
• Grant date: Jan 18, 2022
• Expiry date: May 29, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.