Stable recombinant MVA vectors comprising modified RSV genes with reduced intramolecular recombinatorial activity
US11225673B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Sep 7, 2018 |
| Grant date | Jan 18, 2022 |
| Priority date | — |
| Expiry date | Nov 19, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/22
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide sequences with different bases that do not alter the encoded amino acid sequence. The invention allows for the reduction of intramolecular recombination between homologous nucleotide sequences, in particular in mammalian cells. The invention further relates to nucleotide sequences containing substituted bases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.