Therapeutically triggering an innate immune response in a target tissue
US11226340B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Apr 26, 2017 |
| Grant date | Jan 18, 2022 |
| Priority date | — |
| Expiry date | Apr 26, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides therapeutic compositions that present an artificial repertoire of mammalian pattern recognition receptor (PRR) agonists, so that the pattern of PRR agonists recapitulates a distinct portion of a PRR agonist signature of a mammalian pathogen. The artificial repertoire of PRR agonists may be formulated together in a therapeutic vehicle for combined presentation to an innate immune cell resident in a target tissue in a mammalian host, and the vehicle adapted to deliver the PRR agonists to the target tissue, so as to modulate an immune response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.