Poxvirus vectors encoding HIV antigens, and methods of use thereof

US11229693B2 · kind B2 · utility

Assignees

• Janssen Vaccines & Prevention B.V.
• Bavarian Nordic A/S · DK

Inventors

• Frank Wegmann · Leiden, NL
• Johannes Petrus Maria Langedijk · Amsterdam, NL
• Jerôme Hubertina Henricus Victor Custers · Alphen aan den Rijn, NL
• Viki Bockstal · Borgerhout, BE
• Markus Kalla · Penzberg, DE

Key dates

• Filing date: Jun 14, 2018
• Grant date: Jan 25, 2022
• Expiry date: Jul 25, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16334
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Poxvirus vectors encoding a synthetic HIV envelope antigen and other HIV antigens, as well as compositions containing such poxvirus vectors and uses of such poxvirus vectors as vaccines to provide improved immunity against HIV, are provided. Also provided are vaccine combinations containing the disclosed poxvirus vectors, adenovirus vectors encoding one or more HIV antigens, and one or more isolated HIV antigenic polypeptides, and methods of using the vaccine combinations to provide improved immunity against HIV.