Methods for identifying beta-glucan binding to immune cells
US11229701B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 14, 2013 |
| Grant date | Jan 25, 2022 |
| Priority date | — |
| Expiry date | Feb 27, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2400/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This disclosure describes, in one aspect, a method for identifying β-glucan binding to immune cells of a subject. Generally, the method includes obtaining a blood sample from the subject, the blood sample comprising immune cells, adding soluble β-glucan to at least a portion of the blood sample and incubating the mixture under conditions allowing the soluble β-glucan to bind to the immune cells, and detecting soluble β-glucan bound to the immune cells. In another aspect, this disclosure describes a method that generally includes identifying the subject as a low binder of β-glucan, and co-administering to the subject a soluble β-glucan and an antibody preparation capable of converting the subject from a low binder to a high binder.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.