Conjugates of quaternized tubulysin compounds
US11229708B2 · kind B2 · utility
1Cited by
108References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 2, 2016 |
| Grant date | Jan 25, 2022 |
| Priority date | — |
| Expiry date | Dec 2, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.