Selective disruption of neoplastic cells via resonant harmonic excitation

US11229809B2 · kind B2 · utility

Assignee

• CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

• David Reza Mittelstein · Pasadena, US
• Morteza Gharib · San Marino, US
• Stefanie Heyden · Pasadena, US
• Michael Ortiz · Pasadena, US
• Mikhail G. Shapiro · Los Angeles, US

Key dates

• Filing date: Mar 5, 2018
• Grant date: Jan 25, 2022
• Expiry date: Sep 9, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2205/058
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at a resonance frequency (“oncotripsy”) for the specific cell types are presented. The systems and the methods result in permeabilization, lysis, and/or death of the targeted specific cell types by using ultrasonic harmonic excitations that have a frequency and a pulse duration specifically tuned to disrupt nuclear membranes of the targeted specific cell types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. Target cells may be neoplastic.