Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant P53
US11230578B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | Feb 3, 2017 |
| Grant date | Jan 25, 2022 |
| Priority date | — |
| Expiry date | Feb 3, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.