Methods of using anti-lap antibodies
US11230601B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Oct 10, 2018 |
| Grant date | Jan 25, 2022 |
| Priority date | — |
| Expiry date | Oct 10, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are antibodies which bind to latency-associated peptide (LAP) of TGF-β1 and are characterized by particular functional features, such as binding specifically to LAP-TGFβ1 on cells but not to LAP-TGFβ1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.
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