Cytokine receptor genes and the use thereof to enhance therapy
US11230698B2 · kind B2 · utility
0Cited by
2References
17Claims
0Family size
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Key dates
| Filing date | Jun 21, 2019 |
| Grant date | Jan 25, 2022 |
| Priority date | — |
| Expiry date | Sep 6, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cells, such a T-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise IL-2 and/or IL-15 receptors having increased surface expression or signaling activity. Cells of the embodiments have a significant growth advantage in the presence of cytokines and can be used, e.g., for enhanced adoptive cell transfer therapies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.