Blood brain barrier model and methods of making and using the same
US11230702B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Aug 4, 2017 |
| Grant date | Jan 25, 2022 |
| Priority date | — |
| Expiry date | Nov 12, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2537/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and optionally one or more of astrocytes, pericytes, oligodendrocytes, and microglia. In some embodiments, the model further comprises a porous membrane between said endothelial cell layer and the neuronal cell layer. A microfluidic device comprising the same and methods of use thereof are also provided.
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