Methods for stabilizing production of acetyl-coenzyme A derived compounds
US11230716B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 2, 2020 |
| Grant date | Jan 25, 2022 |
| Priority date | — |
| Expiry date | Jan 2, 2040 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02E50/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure relates to the use of a switch for the production of heterologous non-catabolic compounds in microbial host cells. In one aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured under aerobic conditions followed by microaerobic conditions, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions. In another aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured in the presence of maltose followed by the reduction or absence of maltose, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.