Patent · US Active

Cell engineering using MICRORNAs

US11230725B2 · kind B2 · utility

1Cited by

1References

22Claims

0Family size

Assignee

Boehringer Ingelheim International GmbH · DE

Inventors

Lore Florin · Biberach, DE
Hitto Kaufman · Ulm, DE
Angelika Hausser · Stuttgart, DE
Monilola Olayioye · Stuttgart, DE
Michaela Strotbek · Asperg, DE

Key dates

Filing date	Oct 6, 2017
Grant date	Jan 25, 2022
Priority date	—
Expiry date	Dec 16, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y111/01007
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention concerns the field of cell culture technology. It concerns RNA having a specific sequence, expression vectors encoding the RNA, production host cell lines comprising the RNA, and methods of producing recombinant biopharmaceutical products using engineered host cell with altered levels of the RNAs, such as small non-coding RNAs, preferably microRNAs (miRNAs). The invention also relates to engineered host cells with altered levels in one or more of the RNAs. Those cell lines have improved secretion and/or growth characteristics in comparison to control cell lines.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.