Nucleic acids encoding mosaic conserved region HIV immunogenic polypeptides

US11235055B2 · kind B2 · utility

Assignees

• Triad National Security, LLC · US
• Isis Innovation Limited · GB

Inventors

• Bette T. Korber · Los Alamos, US
• Tomas Hanke · Woodstock, GB
• Andrew McMichael · Felton, GB

Key dates

• Filing date: Jun 29, 2018
• Grant date: Feb 1, 2022
• Expiry date: Aug 8, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16222
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.