Targeted cytotoxic ratjadone derivatives and conjugates thereof

US11236059B2 · kind B2 · utility

Assignee

• Helmholtz-Zentrum Für Infektionsforschung GmbH · DE

Inventors

• Philipp Klahn · Braunschweig, DE
• Mark Broenstrup · Frankfurt am Main, DE
• Verena Fetz · Berlin, DE
• Wera Collisi · Peine, DE
• Katrin I Mohr · Braunschweig, DE
• Stephan Huettel · Braunschweig, DE
• Werner Tegge · Braunschweig, DE

Key dates

• Filing date: Aug 8, 2018
• Grant date: Feb 1, 2022
• Expiry date: Dec 13, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.